03232cam a2200541Ki 4500 9780429353116 FlBoTFG 20260210180825.0 m o d cr cnu---unuuu 191120s2019 si o 000 0 eng d OCoLC-P eng rda pn OCoLC-P 9780429353116 (electronic bk.) 0429353111 (electronic bk.) 9781000707441 (electronic bk. : Mobipocket) 100070744X (electronic bk. : Mobipocket) 9781000707571 (electronic bk. : EPUB) 1000707571 (electronic bk. : EPUB) 9781000707311 (electronic bk. : PDF) 1000707318 (electronic bk. : PDF) 9789814800808 9814800805 (OCoLC)1128094396 (OCoLC-P)1128094396 TP248.E5 MED 009000 bisacsh MED 058170 bisacsh MED 071000 bisacsh TDCW bicssc 660.634 23 Pharmaceutical biocatalysis : chemoenzymatic synthesis of active pharmaceutical ingredients / edited by Peter Grunwald. Singapore : Jenny Stanford Publishing, 2019. 1 online resource (1 volume.) text txt rdacontent computer c rdamedia online resource cr rdacarrier This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals. OCLC-licensed vendor bibliographic record. Enzymes Industrial applications. Biocatalysis. Pharmaceutical chemistry. 1974 MEDICAL / Biotechnology bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh Grunwald, Peter, 1941- editor. Taylor & Francis https://www.taylorfrancis.com/books/9780429353116 OCLC metadata license agreement http://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf 91987 91986