chemoenzymatic synthesis of active pharmaceutical ingredients Grunwald, Peter 1941- editor. text si 2019 monographic eng 1 online resource (1 volume.) This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals. edited by Peter Grunwald. Enzymes Industrial applications Biocatalysis Pharmaceutical chemistry MEDICAL / Biotechnology MEDICAL / Nursing / Pharmacology MEDICAL / Pharmacology TP248.E5 660.634 9780429353116 0429353111 9781000707441 100070744X 9781000707571 1000707571 9781000707311 1000707318 https://www.taylorfrancis.com/books/9780429353116 http://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf https://www.taylorfrancis.com/books/9780429353116 http://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf OCoLC-P 191120 20260210180825.0 9780429353116 eng