05962cam a2200601Ki 4500 9781351235709 FlBoTFG 20260210180907.0 m o d cr cnu---unuuu 191207s2020 flu o 000 0 eng d OCoLC-P eng rda OCoLC-P 9781351235693 electronic book 1351235699 electronic book 9781351235709 electronic book 1351235702 electronic book 9781351235679 electronic book Mobipocket 1351235672 electronic book Mobipocket 9781351235686 electronic book EPUB 1351235680 electronic book EPUB 0815376723 9780815376729 (OCoLC)1130037913 (OCoLC)1129981285 (OCoLC-P)1130037913 QP356.3 .P47 2020 MED 004000 bisacsh MED 056000 bisacsh MED 060000 bisacsh MJD bicssc 612.8042 23 Perlmutter, David, 1954- The Microbiome and the Brain / edited by David Perlmutter. Boca Raton, FL : CRC Press, [2020] 1 online resource (233 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Description based upon print version of record. Cover; Half Title; Title Page; Copyright Page; Contents; Editor; List of Contributors; Introduction; Chapter 1: Assessing the Microbiome-Current and Future Technologies and Applications; Methods for Sequencing the Microbiome; 16S rRNA Sequencing; Shotgun Metagenomic Sequencing; Generating Data from Samples; Common Descriptive Analysis Techniques for Microbiome Data; Diversity Analysis; Relative Abundance Plots; Functional Genomics; Critical Appraisal of Microbiome Data; Simple, Community-Level Analyses-16S rRNA Sequencing; Detailed Metagenomic Analyses-Shotgun Metagenomic Sequencing Bacterial Toxins Breaking the Gut and Blood-Brain BarriersThe Role of LPS in the Breakdown of the Blood-Brain Barrier and the Induction of Pathology in the CNS; Correlation of Intestinal Bacterial LPS Antibody with Occludin/Zonulin, S100B and Aquaporin 4; Association of Gram-Negative Bacterial Molecules (LPS, BCdT) with Alzheimer's Disease (AD); Circulating Antibodies against Bacterial Toxins May Become Pathogenic in the Context of BBB Breakdown; Conclusion; References; Chapter 4: The Microbiome-Its Role in Neuroinflammation: The Autism Spectrum Disorder Paradigm Cross Communication between Brain and Gastrointestinal System: The Gut-Brain AxisCombined Gut and Blood-Brain Barriers Defects; ASD as a Prototypical Example of Gut-Brain Axis Dysfunction; CONCLUSION; References; Chapter 5: Nutrition and the Microbiome-Implications for Autism Spectrum Disorder; Introduction; ASD and Microbiota; ASD and Microbial Metabolites; Gastrointestinal Symptoms and ASD; Nutritional Challenges in Children with ASD; Influence of Diet on Microbiota Composition; Interventions Targeting the Microbiota in ASD to Manage Symptoms Potential Role of Nutrition in the Microbiota-to-Brain Communication in ASDConclusions and Future Directions; References; Chapter 6: Alzheimer's Disease, the Microbiome, and 21st Century Medicine; Looking Forward; References; Chapter 7: Microbial Involvement in Alzheimer's Disease; Introduction: AD and Human Microbiome; Gut Microbiota and Alzheimer's; Impaired Microbiota and Alzheimer's; Human microbiome and risk factors of AD; Targeting Gut Microbiota for AD Interventions; Future Directions; Conclusions; References; Chapter 8: The Role of the Microbiome in Mood; INTRODUCTION The Gut and its Microbiota Brain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And, until recently, these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health, functionality, and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain, through the contributions of some of the most forward thinking researchers and clinicians in the field, comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer's disease, autism, multiple sclerosis, and mood disorders. In addition, mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally, novel therapeutic opportunities, derived from this exciting science are presented. Readers will learn: The highly validated relationship between alterations of gut microbes and their metabolites, and risk for Alzheimer's disease. The important link between autism and intestinal dysbiosis. Appropriate interpretation of available laboratory assessments of the intestinal microbiome. The potential role of fecal microbial transplant in neurological diseases. The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality. OCLC-licensed vendor bibliographic record. MEDICAL / Alternative Medicine bisacsh MEDICAL / Neurology bisacsh MEDICAL / Nutrition bisacsh Brain Microbiology. Human body Microbiology. Taylor & Francis https://www.taylorfrancis.com/books/9781351235709 OCLC metadata license agreement http://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf 93692 93691