05962cam a2200601Ki 45000010014000000030008000140050017000220060019000390070015000580080041000730400031001140200035001450200032001800200035002120200032002470200047002790200044003260200041003700200038004110200015004490200018004640350041004820350024005230500023005470720025005700720025005950720025006200720016006450820017006611000030006782450064007082640041007723000031008133360026008443370026008703380036008965000052009325050594009845050574015785050555021525050587027075000031032945201632033255880047049576500044050046500033050486500033050816500025051146500030051398560072051698560102052419990017053439781351235709FlBoTFG20260210180907.0m     o  d        cr cnu---unuuu191207s2020    flu     o     000 0 eng d  aOCoLC-PbengerdacOCoLC-P  a9781351235693qelectronic book  a1351235699qelectronic book  a9781351235709qelectronic book  a1351235702qelectronic book  a9781351235679qelectronic bookqMobipocket  a1351235672qelectronic bookqMobipocket  a9781351235686qelectronic bookqEPUB  a1351235680qelectronic bookqEPUB  z0815376723  z9780815376729  a(OCoLC)1130037913z(OCoLC)1129981285  a(OCoLC-P)1130037913 4aQP356.3b.P47 2020 7aMEDx0040002bisacsh 7aMEDx0560002bisacsh 7aMEDx0600002bisacsh 7aMJD2bicssc04a612.80422231 aPerlmutter, David,d1954-14aThe Microbiome and the Brain /cedited by David Perlmutter. 1aBoca Raton, FL :bCRC Press,c[2020]  a1 online resource (233 p.)  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  aDescription based upon print version of record.0 aCover; Half Title; Title Page; Copyright Page; Contents; Editor; List of Contributors; Introduction; Chapter 1: Assessing the Microbiome-Current and Future Technologies and Applications; Methods for Sequencing the Microbiome; 16S rRNA Sequencing; Shotgun Metagenomic Sequencing; Generating Data from Samples; Common Descriptive Analysis Techniques for Microbiome Data; Diversity Analysis; Relative Abundance Plots; Functional Genomics; Critical Appraisal of Microbiome Data; Simple, Community-Level Analyses-16S rRNA Sequencing; Detailed Metagenomic Analyses-Shotgun Metagenomic Sequencing8 aBacterial Toxins Breaking the Gut and Blood-Brain BarriersThe Role of LPS in the Breakdown of the Blood-Brain Barrier and the Induction of Pathology in the CNS; Correlation of Intestinal Bacterial LPS Antibody with Occludin/Zonulin, S100B and Aquaporin 4; Association of Gram-Negative Bacterial Molecules (LPS, BCdT) with Alzheimer's Disease (AD); Circulating Antibodies against Bacterial Toxins May Become Pathogenic in the Context of BBB Breakdown; Conclusion; References; Chapter 4: The Microbiome-Its Role in Neuroinflammation: The Autism Spectrum Disorder Paradigm8 aCross Communication between Brain and Gastrointestinal System: The Gut-Brain AxisCombined Gut and Blood-Brain Barriers Defects; ASD as a Prototypical Example of Gut-Brain Axis Dysfunction; CONCLUSION; References; Chapter 5: Nutrition and the Microbiome-Implications for Autism Spectrum Disorder; Introduction; ASD and Microbiota; ASD and Microbial Metabolites; Gastrointestinal Symptoms and ASD; Nutritional Challenges in Children with ASD; Influence of Diet on Microbiota Composition; Interventions Targeting the Microbiota in ASD to Manage Symptoms8 aPotential Role of Nutrition in the Microbiota-to-Brain Communication in ASDConclusions and Future Directions; References; Chapter 6: Alzheimer's Disease, the Microbiome, and 21st Century Medicine; Looking Forward; References; Chapter 7: Microbial Involvement in Alzheimer's Disease; Introduction: AD and Human Microbiome; Gut Microbiota and Alzheimer's; Impaired Microbiota and Alzheimer's; Human microbiome and risk factors of AD; Targeting Gut Microbiota for AD Interventions; Future Directions; Conclusions; References; Chapter 8: The Role of the Microbiome in Mood; INTRODUCTION  aThe Gut and its Microbiota  aBrain related disorders are among the most challenging health issues of our time. The development of effective therapeutic and preventive strategies for these disorders relies on a comprehensive understanding of the underlying causative mechanisms. And, until recently, these mechanisms have remained somewhat elusive. The newly discovered pivotal role of the intestinal microbiome in brain health, functionality, and resistance to disease is revolutionizing neuroscience. The Microbiome and the Brain, through the contributions of some of the most forward thinking researchers and clinicians in the field, comprehensively reveals the leading edge of our understanding of the fundamental role of gut microbes and their metabolites in a wide array of seemingly diverse brain issues including Alzheimer's disease, autism, multiple sclerosis, and mood disorders. In addition, mechanisms defining these relationships are explored along with a presentation of the state-of-the-art as it relates to interpretation of relevant laboratory assessments. Finally, novel therapeutic opportunities, derived from this exciting science are presented. Readers will learn: The highly validated relationship between alterations of gut microbes and their metabolites, and risk for Alzheimer's disease. The important link between autism and intestinal dysbiosis. Appropriate interpretation of available laboratory assessments of the intestinal microbiome. The potential role of fecal microbial transplant in neurological diseases. The influence of diet and other lifestyle choices on the microbiome as it relates to brain health and functionality.  aOCLC-licensed vendor bibliographic record. 7aMEDICAL / Alternative Medicine2bisacsh 7aMEDICAL / Neurology2bisacsh 7aMEDICAL / Nutrition2bisacsh 0aBrainxMicrobiology. 0aHuman bodyxMicrobiology.403Taylor & Francisuhttps://www.taylorfrancis.com/books/9781351235709423OCLC metadata license agreementuhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf  c93692d93691